Multinomial model-based formulations of TCP and NTCP for radiotherapy treatment planning
نویسندگان
چکیده
منابع مشابه
Multinomial model-based formulations of TCP and NTCP for radiotherapy treatment planning.
Hit and target models of tumor growth, typically assume that all surviving cells have a constant and homogeneous sensitivity during the radiotherapy period. In this study, we propose a new multinomial model based on a discrete-time Markov chain, able to take into account cell repair, cell damage heterogeneity and cell proliferation. The proposed model relies on the 'Hit paradigm' and 'Target' t...
متن کاملLinear Programming Formulations and Algorithms for Radiotherapy Treatment Planning
Optimization has become an important tool in treatment planning for cancer radiation therapy. It may be used to determine beam weights, beam directions, and appropriate use of beam modifiers such as wedges and blocks, with the aim of delivering a required dose to the tumor while sparing nearby critical structures and normal tissue. Linear programming formulations are a core computation in many ...
متن کاملLinear programing formulations and algorithms for radiotherapy treatment planning
Optimization has become an important tool in treatment planning for cancer radiation therapy. It may be used to determine beam weights, beam directions, and appropriate use of beam modifiers such as wedges and blocks, with the aim of delivering a required dose to the tumor, while sparing nearby critical structures and normal tissue. Linear programing formulations are a core computation in many ...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 2011
ISSN: 0022-5193
DOI: 10.1016/j.jtbi.2011.03.025